2-Acetoxyisobutyroyl chloride → HCID 68663477, compound

HRID 452669Notes

Reaction equation

HRID 452669 reaction equation
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]3[CH:15]=[C:16]([C:19]([NH:21][NH2:22])=[O:20])[CH:17]=[CH:18][C:13]=3[N:12]=[CH:11]2)=[CH:6][CH:5]=1.[C:25]([O:28][C:29]([CH3:34])([CH3:33])[C:30](Cl)=[O:31])(=[O:27])[CH3:26]>>[C:25]([O:28][C:29]([CH3:34])([CH3:33])[C:30](=[O:31])[NH:22][NH:21][C:19]([C:16]1[CH:17]=[CH:18][C:13]2[N:12]=[CH:11][N:10]([C:7]3[CH:6]=[CH:5][C:4]([O:3][C:2]([F:1])([F:23])[F:24])=[CH:9][CH:8]=3)[C:14]=2[CH:15]=1)=[O:20])(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 1234962-Acetoxyisobutyroyl chlorideHCID 68664363HCID 68664363, compound

Product 1

HCID 68663477HCID 68663477, compoundYield 66%

Procedure

In the same manner as in Reference Example 129 and using 1-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole-6-carbohydrazide instead of 3-bromo-1-benzofuran-5-carbohydrazide and 2-chloro-1,1-dimethyl-2-oxoethyl acetate instead of (1S)-2-chloro-1-methyl-2-oxoethyl acetate, the title compound (yield 66%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-ccb68aba67a0408495b156d959e58a15
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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