Hydrazine hydrate (1:1) → N-cyclopentyl-N-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]-6-hydrazinylpyridine-3-sulfonamide

HRID 45268Notes

Reaction equation

HRID 45268 reaction equation
[CH3:1][C:2]1([CH3:15])[O:7][CH2:6][CH:5]([CH2:8][NH:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:4][O:3]1.Cl[C:17]1[N:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.O.[NH2:28][NH2:29]>>[CH:10]1([N:9]([CH2:8][CH:5]2[CH2:4][O:3][C:2]([CH3:15])([CH3:1])[O:7][CH2:6]2)[S:23]([C:20]2[CH:21]=[N:22][C:17]([NH:28][NH2:29])=[CH:18][CH:19]=2)(=[O:25])=[O:24])[CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 27927922-Chloro-5-pyridinesulfonyl chlorideHCID 67455188N-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]cyclopentanamine

Product 1

HCID 67453901N-cyclopentyl-N-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]-6-hydrazinylpyridine-3-sulfonamide

Procedure

The compound is prepared according to processes 14.1 and 5.2, starting with N-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]cyclopentanamine, 6-chloropyridine-3-sulfonyl chloride and hydrazine hydrate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-4bb281048f28408e8885ca421d2baf5d
Source dataset
uspto-grants-2013_09
Patent number
US08541455B2

Reaction notes

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