HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452770Generated: October 26, 2026
Triethyl orthoacetate → 4-(5-methyl-1,3,4-oxadiazol-2-yl)-N-[4-(methylthio)phenyl]pyridin-2-amine
https://huagongshe.com/reaction/452770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethyl orthoacetate | HCID 66221 | — |
| Reactant | 2-[[4-(Methylthio)phenyl]amino]isonicotinohydrazide | HCID 68664110 | — |
| Product | 4-(5-methyl-1,3,4-oxadiazol-2-yl)-N-[4-(methylthio)phenyl]pyridin-2-amine | HCID 68663319 | 80% |
Reaction Steps
A mixture of 2-[[4-(methylthio)phenyl]amino]isonicotinohydrazide (511 mg, 1.86 mmol) and triethyl orthoacetate (10 mL) was stirred at 120° C. overnight. After cooling, the precipitate was collected by filtration and recrystallized from hexane/ethyl acetate to give the title compound (441 mg, yield 80%) as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492378B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-88fb69ffd929441a82071c08e8f5a36e |
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| Source note | uspto-grants-2013_07 |
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