4-(Methylthio)-3-(trifluoromethyl)benzyl chloride → 6-[5-[[4-(Methylthio)-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazol-2-yl]benzothiazole
Reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:16][S:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Cl)=[CH:20][C:19]=1[C:26]([F:29])([F:28])[F:27]>>[CH3:16][S:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][S:15][C:13]2[O:14][C:10]([C:7]3[CH:8]=[CH:9][C:4]4[N:3]=[CH:2][S:1][C:5]=4[CH:6]=3)=[N:11][N:12]=2)=[CH:20][C:19]=1[C:26]([F:27])([F:29])[F:28]Participants
3
Procedure
In the same manner as in Example 7 and using 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 4-(methylthio)-3-(trifluoromethyl)benzyl chloride instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 94%) was obtained as colorless crystals.
Sources & evidence
- ORD record
- ord-006920d7b7ea44d086c7fd21c0413fbf
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08492378B2
Reaction notes
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