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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452774Generated: October 30, 2026

4-(Methylthio)-3-(trifluoromethyl)benzyl chloride → 6-[5-[[4-(Methylthio)-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazol-2-yl]benzothiazole

https://huagongshe.com/reaction/452774

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Methylthio)-3-(trifluoromethyl)benzyl chlorideHCID 68663128—
ReactantHCID 178527938HCID 178527938—
Product6-[5-[[4-(Methylthio)-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazol-2-yl]benzothiazoleHCID 6866288194%

Reaction Steps

In the same manner as in Example 7 and using 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 4-(methylthio)-3-(trifluoromethyl)benzyl chloride instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 94%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-006920d7b7ea44d086c7fd21c0413fbf
Source noteuspto-grants-2013_07