Dimethylformamide → HCID 68663978, compound

HRID 452800Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([NH2:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[S:8][CH3:9].CN(C)C=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([NH2:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:9])=[O:28]

Participants

Reactant 2

HCID 6228Dimethylformamide

HCID 68664212HCID 68664212, compound

Product 1

HCID 68663978HCID 68663978, compoundYield 84%

Procedure

In the same manner as in Example 140 and using 5-[3-[3-chloro-4-(methylthio)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-amine instead of 2-methyl-5-[3-[4-(methylthio)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole and using N,N-dimethylformamide instead of dichloromethane, the title compound (yield 84%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-93a4d2fec9804fe5aa2f97cb7a91451b
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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