Piperazine → HCID 68664066, compound

HRID 452804Notes

Reaction equation

HRID 452804 reaction equation
CS([C:5]1[O:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]3[O:17][CH:16]=[C:15]([C:18]4[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=4)[C:14]=3[CH:29]=2)=[N:8][N:9]=1)(=O)=O.[NH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[F:26][C:25]([F:28])([F:27])[O:24][C:21]1[CH:22]=[CH:23][C:18]([C:15]2[C:14]3[CH:29]=[C:10]([C:7]4[O:6][C:5]([N:30]5[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]5)=[N:9][N:8]=4)[CH:11]=[CH:12][C:13]=3[O:17][CH:16]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 686643602-(Methylsulfonyl)-5-[3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole

Product 1

HCID 68664066HCID 68664066, compoundYield 20%

Procedure

In the same manner as in Example 110 and using 2-(methylsulfonyl)-5-[3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole instead of 2-(2,3-dihydro-1-benzofuran-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole and using piperazine instead of 3-fluorobenzylalcohol, the title compound (yield 20%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-f6df19551c0d4fd588c0d1946326f47c
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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