Methylamine tetrahydrofuran → HCID 68663400, compound

HRID 452812Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[C:14]([C:17]3[O:18][C:19](S(C)(=O)=O)=[N:20][N:21]=3)[CH:15]=[CH:16][C:11]=2[O:10][CH:9]=1.[CH3:26][NH2:27].O1CCCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[C:14]([C:17]3[O:18][C:19]([NH:27][CH3:26])=[N:20][N:21]=3)[CH:15]=[CH:16][C:11]=2[O:10][CH:9]=1

Participants

Reactant 2

HCID 66615946Methylamine tetrahydrofuran

HCID 68663200HCID 68663200, compound

Product 1

HCID 68663400HCID 68663400, compoundYield 65%

Procedure

In the same manner as in Example 110 and using 2-[3-(2-chlorophenyl)-1-benzofuran-5-yl]-5-(methylsulfonyl)-1,3,4-oxadiazole instead of 2-(2,3-dihydro-1-benzofuran-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole and using 2M methylamine-tetrahydrofuran solution instead of 3-fluorobenzylalcohol, the title compound (yield 65%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-deee75910ed343c09678b2af81664805
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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