Methanol → HCID 68663868, compound

HRID 452816Notes

Reaction equation

HRID 452816 reaction equation
CS([C:5]1[O:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]3[O:17][CH:16]=[C:15]([C:18]4[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=4)[C:14]=3[CH:29]=2)=[N:8][N:9]=1)(=O)=O.[CH3:30][OH:31]>>[CH3:30][O:31][C:5]1[O:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]3[O:17][CH:16]=[C:15]([C:18]4[CH:19]=[CH:20][C:21]([O:24][C:25]([F:28])([F:26])[F:27])=[CH:22][CH:23]=4)[C:14]=3[CH:29]=2)=[N:8][N:9]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 686643602-(Methylsulfonyl)-5-[3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole

Product 1

HCID 68663868HCID 68663868, compoundYield 4%

Procedure

In the same manner as in Example 110 and using 2-(methylsulfonyl)-5-[3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole instead of 2-(2,3-dihydro-1-benzofuran-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole and using methanol instead of 3-fluorobenzyl alcohol, the title compound (yield 4%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-af37050f2955438d8bb8af30b635f033
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

Loading…