HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine tetrahydrofuran → HCID 68664750, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine tetrahydrofuran | HCID 66615946 | — |
| Reactant | HCID 68664444 | HCID 68664444 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 68664750 | HCID 68664750 | 79% |
Reaction Steps
In the same manner as in Example 433 and using 6-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl]-1-[3-(trifluoromethoxy)phenyl]-1H-benzimidazole instead of 6-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl]-1-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole, using 2M methylamine-tetrahydrofuran solution instead of sodium methoxide, and using 1-methyl-2-pyrrolidone instead of N,N-dimethylformamide, the title compound (yield 79%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-da8c9f0a6b024fa0a13e9f77d8bd20b2 |
| Source note | uspto-grants-2013_07 |