Methylamine tetrahydrofuran → HCID 68664750, compound

HRID 452825Notes

Reaction equation

HRID 452825 reaction equation
CS([C:5]1[O:9][C:8]([C:10]2[CH:11]=[CH:12][C:13]3[N:17]=[CH:16][N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]([F:28])([F:27])[F:26])[CH:19]=4)[C:14]=3[CH:29]=2)=[N:7][N:6]=1)(=O)=O.[CH3:30][NH2:31].O1CCCC1>CN1CCCC1=O>[CH3:30][NH:31][C:5]1[O:9][C:8]([C:10]2[CH:11]=[CH:12][C:13]3[N:17]=[CH:16][N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]([F:28])([F:27])[F:26])[CH:19]=4)[C:14]=3[CH:29]=2)=[N:7][N:6]=1

Participants

4

Reactant 2

HCID 66615946Methylamine tetrahydrofuranHCID 68664444HCID 68664444, compound

Product 1

HCID 68664750HCID 68664750, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In the same manner as in Example 433 and using 6-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl]-1-[3-(trifluoromethoxy)phenyl]-1H-benzimidazole instead of 6-[5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl]-1-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole, using 2M methylamine-tetrahydrofuran solution instead of sodium methoxide, and using 1-methyl-2-pyrrolidone instead of N,N-dimethylformamide, the title compound (yield 79%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-da8c9f0a6b024fa0a13e9f77d8bd20b2
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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