HCID 44464432, compound → HCID 44464431, compound

HRID 453263Notes

Reaction equation

HRID 453263 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([N:13]1[C:17]([CH3:18])=[CH:16][C:15]([O:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[N:14]1)[CH:7]=[CH:6]2>Cl>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([N:13]1[C:17]([CH3:18])=[CH:16][C:15]([O:19][CH2:20][CH2:21][N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)=[N:14]1)[CH:7]=[CH:6]2

Participants

3

Reactant 1

HCID 44464432HCID 44464432, compound

Product 1

HCID 44464431HCID 44464431, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4-{2-[1-(6-methoxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine (448 mg, 1.22 mmol) in HCl conc. (5 ml) was heated to reflux during 7 hrs, it was cooled and evaporated to dryness in a rotavapor. 375 mg of 4-{2-[1-(6-hydroxynaphthalen-2-yl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}morpholine chlorhydrate were obtained in amorphous solid form that was highly hygroscopic (yield: 79%)

Workup

  1. temperatureto reflux during 7 hrs
  2. temperatureit was cooled
  3. customevaporated to dryness in a rotavapor

Sources & evidence

ORD record
ord-dbdd621b26904c5f8eb1b6aa8937b16b
Source dataset
uspto-grants-2013_07
Patent number
US08492425B2

Reaction notes

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