反应详情

A solution of tert-butyl 5-methyl-2-phenylthiazole-4-carboxylate (1.0 g. 3.64 mmol), N-bromosuccinimide (NBS) (0.65 g 3.64 mmol), and benzoyl peroxide (BPO) (5.5 mg, 0.023 mmol) in CCl4 (30 ml) was heated at reflux for 16 h. The reaction mixture was concentrated in vacuo and purified by flash chromatography to give tert-butyl 5-(bromomethyl)-2-phenylthiazole-4-carboxylate as a light yellow solid (0.96 g, 75% yield).

1. temperatureat reflux for 16 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. custompurified by flash chromatography