HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Tert-butyl 5-(bromomethyl)-2-phenylthiazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Tert-butyl 5-methyl-2-phenylthiazole-4-carboxylate | HCID 67424508 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Tert-butyl 5-(bromomethyl)-2-phenylthiazole-4-carboxylate | HCID 67424804 | 75% |
Reaction Steps
A solution of tert-butyl 5-methyl-2-phenylthiazole-4-carboxylate (1.0 g. 3.64 mmol), N-bromosuccinimide (NBS) (0.65 g 3.64 mmol), and benzoyl peroxide (BPO) (5.5 mg, 0.023 mmol) in CCl4 (30 ml) was heated at reflux for 16 h. The reaction mixture was concentrated in vacuo and purified by flash chromatography to give tert-butyl 5-(bromomethyl)-2-phenylthiazole-4-carboxylate as a light yellow solid (0.96 g, 75% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492401B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-c0d931a190b44efa8c854b82319954b1 |
| Source note | uspto-grants-2013_07 |