HRID453312

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID318533

5-methyl-2-phenyloxazole-4-carboxylic acid

C11H9NO3

结构：COCCN1CCN(Cc2cnc3sc(-c4ccccc4N)nc3c2)CC1

HCID58551870

未命名化合物

PRODUCTS

生成物

结构：COCCN1CCN(Cc2cnc3sc(-c4ccccc4NC(=O)c4nc(-c5ccccc5)oc4C)nc3c2)CC1

HCID46244963

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 5-methyl-2-phenyloxazole-4-carboxylic acid (1.5 eq). The product precipitated from the reaction mixture, and was filtered and chased with methanol. The product was purified by prep HPLC. MS Calcd for C31H32N6O3S: 568.23. Found (M+H)+ m/z=569.

WORKUP

后处理

customThe product precipitated from the reaction mixture
filtrationwas filtered
customThe product was purified by prep HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dbfdb232903c4b31b552446631a67621
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08492401B2
来源说明: uspto-grants-2013_07

反应 SMILES

[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:13]=[C:14]3[N:20]=[C:19]([C:21]4[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=4[NH2:23])[S:18][C:15]3=[N:16][CH:17]=2)[CH2:7][CH2:6]1.[CH3:28][C:29]1[O:33][C:32]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[N:31][C:30]=1[C:40](O)=[O:41]>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:13]=[C:14]3[N:20]=[C:19]([C:21]4[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=4[NH:23][C:40]([C:30]4[N:31]=[C:32]([C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)[O:33][C:29]=4[CH3:28])=[O:41])[S:18][C:15]3=[N:16][CH:17]=2)[CH2:7][CH2:6]1