5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid → N-(2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-5-methyl-2-phenyloxazole-4-carboxamide

Participants

Reaction Steps

The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 5-methyl-2-phenyloxazole-4-carboxylic acid (1.5 eq). The product precipitated from the reaction mixture, and was filtered and chased with methanol. The product was purified by prep HPLC. MS Calcd for C31H32N6O3S: 568.23. Found (M+H)+ m/z=569.

Provenance & Evidence