Diisopropylethylamine → HCID 59381877, compound

HRID 453378Notes

Reaction equation

HRID 453378 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][C:13]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)=[CH:19][CH:18]=2)=[N:14][CH:15]=1)=[O:8].C(N(C(C)C)CC)(C)C.[C:41](Cl)(=[O:52])[O:42][C:43]1[C:48]([CH3:49])=[CH:47][C:46]([CH3:50])=[CH:45][C:44]=1[CH3:51]>CN(C)C1C=CN=CC=1.ClCCl>[CH3:31][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:41](=[O:52])[O:42][C:43]2[C:48]([CH3:49])=[CH:47][C:46]([CH3:50])=[CH:45][C:44]=2[CH3:51])=[CH:30][C:6]=1[C:7](=[O:8])[NH:9][C:10]1[CH:11]=[N:12][C:13]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]3)=[CH:19][CH:18]=2)=[N:14][CH:15]=1

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 11106338HCID 11106338, compoundHCID 16118190HCID 16118190, compound

Product 1

HCID 59381877HCID 59381877, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent2×

Procedure

A 16×100 mm vial was charged with 5-amino-2-methyl-N-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-5-yl)benzamide 30 (0.100 g, 0.24 mmol), 4-(dimethylamino)pyridine (0.0059 g, 0.048 mmol), dichloromethane (2 mL), and diisopropylethylamine (0.050 ml, 0.29 mmol). A solution of mesityl carbonochloridate (0.048 g, 0.24 mmol) in dichloromethane (1 mL) was added dropwise and the reaction mixture stirred at room temperature for 20 hours. The reaction mixture was purified via column chromatography on silica gel (gradient elution with 0 to 20% methanol in dichloromethane) to afford mesityl 4-methyl-3-((2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-5-yl)carbamoyl)phenylcarbamate 47 as a bright yellow solid. MS m/z found 580 [MH+]; calc. for C33H37N7O3=579.69.

Workup

  1. customThe reaction mixture was purified via column chromatography on silica gel (gradient elution with 0 to 20% methanol in dichloromethane)

Sources & evidence

ORD record
ord-f5b2e7cca7514488818506360fd93a28
Source dataset
uspto-grants-2013_07
Patent number
US08492404B2

Reaction notes

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