反应详情

A mixture of tert-butyl 4-oxopiperidine-1-carboxylate (1.00 g), benzyl mercaptan (2.48 g), nitromethane (3.05 g), ethylenediamine (0.3 g) and acetonitrile (15 mL) was heated under reflux for 8 hr. The reaction solution was concentrated under, reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9-3:1) to give the title compound (1.3 g, yield 71%) as colorless crystals.

1. temperaturewas heated
2. temperatureunder reflux for 8 hr
3. concentrationThe reaction solution was concentrated under, reduced pressure
4. customthe obtained residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9-3:1)