Magnesium Chloride → HCID 178488035, compound

HRID 453675Notes

Reaction equation

HRID 453675 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[Na+].[Mg+2:26].[Cl-].[Cl-]>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[Mg+2:26]

Participants

4

Reactant 2

HCID 5360315Magnesium ChlorideHCID 178488037HCID 178488037, compound

Product 1

HCID 178488035HCID 178488035, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Esomeprazole sodium (5 g; 13.61 mmol; e.e. of 99.98%), was dissolved in DM water (63 ml) and filtered. To the filtrate, anhydrous MgCl2 (0.648 g; 6.8 mmol) dissolved in DM water (25 ml) was added drop wise and stirred for 1 h. The precipitated product was filtered, washed with DM water and dried under reduced pressure at 40° C. to yield of amorphous esomeprazole magnesium trihydrate.

Workup

  1. filtrationfiltered
  2. additionwas added drop wise
  3. filtrationThe precipitated product was filtered
  4. washwashed with DM water
  5. dry with materialdried under reduced pressure at 40° C. to yield of amorphous esomeprazole magnesium trihydrate

Sources & evidence

ORD record
ord-7b0c1576c0834f3e8e179fbc57b9d815
Source dataset
uspto-grants-2013_07
Patent number
US08492551B2

Reaction notes

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