反应详情

Esomeprazole sodium (5 g; 13.61 mmol; e.e. of 99.98%), was dissolved in DM water (63 ml) and filtered. To the filtrate, anhydrous MgCl2 (0.648 g; 6.8 mmol) dissolved in DM water (25 ml) was added drop wise and stirred for 1 h. The precipitated product was filtered, washed with DM water and dried under reduced pressure at 40° C. to yield of amorphous esomeprazole magnesium trihydrate.

1. filtrationfiltered
2. additionwas added drop wise
3. filtrationThe precipitated product was filtered
4. washwashed with DM water
5. dry with materialdried under reduced pressure at 40° C. to yield of amorphous esomeprazole magnesium trihydrate