Magnesium Chloride → HCID 178488035, compound

Participants

Reaction Steps

Esomeprazole sodium (5 g; 13.61 mmol; e.e. of 99.98%), was dissolved in DM water (63 ml) and filtered. To the filtrate, anhydrous MgCl2 (0.648 g; 6.8 mmol) dissolved in DM water (25 ml) was added drop wise and stirred for 1 h. The precipitated product was filtered, washed with DM water and dried under reduced pressure at 40° C. to yield of amorphous esomeprazole magnesium trihydrate.

Provenance & Evidence