HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86660299, compound → (R)-((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86660299 | HCID 86660299 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (R)-((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate | HCID 59401133 | 110.6% |
Reaction Steps
(R)—((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate (1S,2S)-1,2-dicarboxyethane-1,2-bis(olate) (diastereomer 1 of I8) (535 mg, 1.25 mmol) was dissolved in EtOAc (250 mL) and washed with saturated Na2CO3 solution (50 ml). The organic phase was dried over Na2SO4, filtered and evaporated to give (R)—((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate (490 mg; 45% yield, single diastereomer).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492548B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-21b9fad7dbb64fcb95c208578d1b4706 |
| Source note | uspto-grants-2013_07 |