反应详情

(R)—((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate (1S,2S)-1,2-dicarboxyethane-1,2-bis(olate) (diastereomer 1 of I8) (535 mg, 1.25 mmol) was dissolved in EtOAc (250 mL) and washed with saturated Na2CO3 solution (50 ml). The organic phase was dried over Na2SO4, filtered and evaporated to give (R)—((R)-quinuclidin-3-yl) 2-(4-fluorophenylamino)-2-phenylacetate (490 mg; 45% yield, single diastereomer).

1. washwashed with saturated Na2CO3 solution (50 ml)
2. dry with materialThe organic phase was dried over Na2SO4
3. filtrationfiltered
4. customevaporated