反应详情

To a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (diastereomer 1 of I2) (75 mg, 0.22 mmol) in EtOAc (5 ml), was added ethyl 4-(2-bromoacetyl)benzoate (I12) (66.5 mg, 0.24 mmol), and the reaction was stirred at room temperature for 15 hours. The solvent was evaporated and the crude was triturated with i-Pr2O-EtOAc (1/1) to obtain (R)-1-(2-(4-(ethoxycarbonyl)phenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (128.5 mg, 95% yield).

1. customThe solvent was evaporated
2. customthe crude was triturated with i-Pr2O-EtOAc (1/1)