反应详情

To a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (300 mg, 0.89 mmol) in EtOAc (5 ml), was added 4-(2-bromoacetyl)benzoic acid (238 mg, 0.98 mmol), and the reaction was stirred at r.t. for 15 hours. The precipitate was collected by suction filtration to obtain (R)-1-(2-(4-carboxyphenyl)-2-oxoethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (500 mg, 97% yield).

1. filtrationThe precipitate was collected by suction filtration