4-Bromophenyl isocyanate → HCID 71571934, compound

HRID 453717Notes

Reaction equation

HRID 453717 reaction equation
[NH2:1][N:2]1[C:6](=[O:7])[C:5]([CH2:10][CH3:11])([CH2:8][CH3:9])[NH:4][C:3]1=[O:12].[Br:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:1][N:2]2[C:6](=[O:7])[C:5]([CH2:10][CH3:11])([CH2:8][CH3:9])[NH:4][C:3]2=[O:12])=[O:22])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 756094-Bromophenyl isocyanateHCID 86684670HCID 86684670, compound

Product 1

HCID 71571934HCID 71571934, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3-amino-5,5-diethylimidazolidine-2,4-dione CAS 1007-61-0 (70 mg, 0.4 mmol), 4-bromophenylisocyanate CAS 2493-02-9 (80 mg, 0.4 mmol) in toluene (5 mL) was heated at 100° C. for 8 h. Upon cooling the reaction to ambient temperature, Compound 1 separated as a white solid, which was collected by filtration and dried under high vacuum.

Workup

  1. temperatureUpon cooling
  2. customthe reaction to ambient temperature
  3. customCompound 1 separated as a white solid, which
  4. filtrationwas collected by filtration
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-23207be0d57c4e2ebe765cedb92003d5
Source dataset
uspto-grants-2013_07
Patent number
US08492556B2

Reaction notes

Loading…