反应详情

温度

25 °C

Methyl 3-chloro-1H-pyrrole-2-carboxylate (18.86 mmol, 1.0 equiv.) was dissolved in MeOH—H2O (2:1, 120 ml); at 0° C., LiOH.H2O (75.4 mmol, 4 equiv.) was added and the mixture was stirred for 16 h at 25° C. The methanol was concentrated under reduced pressure, and the aqueous residue was diluted with water (60 ml) and extracted with ethyl acetate (2×50 ml). The aqueous phase was adjusted to pH 3-4 with 1 M HCl, and the resulting solid was filtered out. Yield: 90%

1. concentrationThe methanol was concentrated under reduced pressure
2. additionthe aqueous residue was diluted with water (60 ml)
3. extractionextracted with ethyl acetate (2×50 ml)
4. filtrationthe resulting solid was filtered out