Hydrochloric Acid → HCID 67369868, compound

HRID 453891Notes

Reaction equation

HRID 453891 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][C:12]([N:20]([CH3:22])[CH3:21])([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.CCOC(C)=O.CCCCCC>C(Cl)(Cl)Cl>[ClH:1].[ClH:1].[CH3:21][N:20]([CH3:22])[C:12]1([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21226206Ethyl acetate hexaneHCID 57831240HCID 57831240, compound

Product 1

HCID 67369868HCID 67369868, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

HCl gas was passed through a solution of 6 g (1 eq.) tert-butyloxycarbonyl-4-(dimethylamino)-4-(thiophen-2-yl)piperidine in 120 ml chloroform at 0° C. for 1 h. The reaction course was monitored by thin-layer chromatography (75% EtOAc/hexane). Once the conversion was complete, the solvent was removed under reduced pressure and 5.3 g (98%) of product were obtained in the form of a white solid.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-082771a2dfbe4f7baa2ca51400232ab8
Source dataset
uspto-grants-2013_07
Patent number
US08492559B2

Reaction notes

Loading…