Hydrochloric Acid → HCID 68422483, compound

HRID 453904Notes

Reaction equation

HRID 453904 reaction equation
[ClH:1].[N:2]1([CH2:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][N:14]([CH:19]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]2)[CH2:13][CH2:12]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>CO>[ClH:1].[ClH:1].[ClH:1].[N:2]1([CH2:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][N:14]([CH:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)[CH2:13][CH2:12]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68490368HCID 68490368, compound

Product 1

HCID 68422483HCID 68422483, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.25 M hydrogen chloride in methanol (11 ml) was added to tert-butyl 3-(6-(piperidin-1-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-1-carboxylate (0.55 g, 1.38 mmol), and the mixture was refluxed for 3 h. The solvent was removed under vacuum and the residue was taken up in ethanol/acetone (5 ml). Diethyl ether (20 ml) was then added, and the resulting precipitate was filtered out and dried under vacuum. Yield: 0.41 g (73%)

Workup

  1. temperaturethe mixture was refluxed for 3 h
  2. customThe solvent was removed under vacuum
  3. additionDiethyl ether (20 ml) was then added
  4. filtrationthe resulting precipitate was filtered out
  5. customdried under vacuum

Sources & evidence

ORD record
ord-7c83cf58f776444e8a8950be86634e45
Source dataset
uspto-grants-2013_07
Patent number
US08492559B2

Reaction notes

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