HRID453949

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61186

Valeryl chloride

C5H9ClO

结构：COC(=O)[C@@H](NCc1ccc(-c2ccccc2C#N)cc1)C(C)C

HCID16744794

Methyl N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-L-valinate

C20H22N2O2

PRODUCTS

生成物

HCID61186

Valeryl chloride

C5H9ClO

结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OC)C(C)C

HCID16744795

N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester

C25H30N2O3

PROCEDURE

实验过程

According to US 2006/0149079 A1 N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methylester is acylated with valerylchloride in the presence of inorganic base to give N-[(2′-cyanobiphenyl-4-yl)methyl]-N-valeryl-(L)-valine methylester with valerylchloride, followed by the conversion of cyano to tetrazole and hydrolyzing the tetrazole derivative to obtain valsartan.