Valeryl chloride → Valeryl chloride

Participants

Role	Name	HCID	Charge
Reactant	Valeryl chloride	HCID 61186	—
Reactant	N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-L-valine methyl ester	HCID 16744794	—
Product	Valeryl chloride	HCID 61186	—
Product	N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-N-(1-oxopentyl)-L-valine methyl ester	HCID 16744795	—

Reaction Steps

According to US 2006/0149079 A1 N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methylester is acylated with valerylchloride in the presence of inorganic base to give N-[(2′-cyanobiphenyl-4-yl)methyl]-N-valeryl-(L)-valine methylester with valerylchloride, followed by the conversion of cyano to tetrazole and hydrolyzing the tetrazole derivative to obtain valsartan.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08492577B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-8a943008a0814b1da97cc487f2d9b617
Source note	uspto-grants-2013_07