反应详情

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (36.95 g, 105.5 mmol) was suspended in TFA (420 ml) and heated at reflux for 3 hours. The reaction mixture was allowed to cool and evaporated under vacuum. The residue was stirred mechanically in water then basified with saturated aqueous sodium hydrogen carbonate solution and stirred overnight. The water was decanted and the solid suspended in acetone. After stirring the white solid was collected by filtration, washed with acetone and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (26.61 g, 96%).

1. temperatureheated
2. temperatureat reflux for 3 hours
3. temperatureto cool
4. customevaporated under vacuum
5. stirringstirred overnight
6. customThe water was decanted
7. stirringAfter stirring the white solid
8. filtrationwas collected by filtration
9. washwashed with acetone
10. customdried