反应详情

A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane is refluxed, whilst stirring, for 2-3 hours in 300 ml of acetonitrile. The reaction mixture is filtered whilst still warm, the filtrate concentrated by evaporation and the residue recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide having a melting point of 120°-121° is obtained.

1. temperatureis refluxed
2. filtrationThe reaction mixture is filtered
3. temperaturewhilst still warm
4. concentrationthe filtrate concentrated by evaporation
5. customthe residue recrystallised from a little methanol