Dimethylformamide → 4-Chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazoline

HRID 454017Notes

Reaction equation

HRID 454017 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1)[N:9]=[CH:8][NH:7][C:6]2=O.CN(C=O)C.S(Cl)([Cl:30])=O>>[Cl:30][C:6]1[C:5]2[C:10](=[CH:11][C:12]([O:13][CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[N:9]=[CH:8][N:7]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 1354703756-Methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4(3H)-one

Product 1

HCID 117822304-Chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolineYield 98%

Conditions

Temperature
85 °C

Procedure

A solution of 6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)-3,4-dihydroquinazolin-4-one (2.8 g, 9.24 mmol) in thionyl chloride (28 ml) containing DMF (280 μl) was refluxed at 85° C. for 1 hour. After cooling, the volatiles were removed by evaporation. The precipitate was triturated with ether, filtered, washed with ether and dried under vacuum. The solid was dissolved in methylene chloride and saturated aqueous sodium hydrogen carbonate was added. The organic layer was separated, washed with water, brine, dried (MgSO4) and evaporated to give 4-chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazoline (2.9 g, 98%).

Workup

  1. temperatureAfter cooling
  2. customthe volatiles were removed by evaporation
  3. customThe precipitate was triturated with ether
  4. filtrationfiltered
  5. washwashed with ether
  6. customdried under vacuum
  7. dissolutionThe solid was dissolved in methylene chloride
  8. additionsaturated aqueous sodium hydrogen carbonate was added
  9. customThe organic layer was separated
  10. washwashed with water, brine
  11. dry with materialdried (MgSO4)
  12. customevaporated

Sources & evidence

ORD record
ord-0b3656b219e448398be061911ecb299b
Source dataset
uspto-grants-2013_07
Patent number
US08492560B2

Reaction notes

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