HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178446042, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | {(S)-1-[(R)-6,8-Dichloro-3-((S)-1-cyano-3-methyl-butylcarbamoyl)-2,3,4,9-tetrahydro-1H-carbazol-3-ylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester | HCID 67291686 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178446042 | HCID 178446042 | — |
Reaction Steps
0.122 g (0.19 mmol) of {(5)-1-[(R)-6,8-Dichloro-3-((S)-1-cyano-3-methyl-butylcarbamoyl)-2,3,4,9-tetrahydro-1H-carbazol-3-ylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester synthesized according to 84 (see below), 0.028 g (0.44 mmol) of sodium azide and 0.026 (0.48 mmol) of ammonium chloride were heated in 2 mL of DMF in a microwave at 110° C. and 100 watt for 6 h. The reaction solution was separated on a preparative HPLC column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541462B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-dd7d7b6d9e3043f59fb9ab8dad77dbe8 |
| Source note | uspto-grants-2013_09 |