HRID45410

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25517

未命名化合物

HCID33557

未命名化合物

结构：CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@]1(C(=O)N[C@H](C#N)CC(C)C)CCc2[nH]c3c(Cl)cc(Cl)cc3c2C1

HCID67291686

未命名化合物

PRODUCTS

生成物

结构：CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@]1(C(=O)N[C@@H](CC(C)C)c2nnn[nH]2)CCc2[nH]c3c(Cl)cc(Cl)cc3c2C1

HCID178446042

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.122 g (0.19 mmol) of {(5)-1-[(R)-6,8-Dichloro-3-((S)-1-cyano-3-methyl-butylcarbamoyl)-2,3,4,9-tetrahydro-1H-carbazol-3-ylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester synthesized according to 84 (see below), 0.028 g (0.44 mmol) of sodium azide and 0.026 (0.48 mmol) of ammonium chloride were heated in 2 mL of DMF in a microwave at 110° C. and 100 watt for 6 h. The reaction solution was separated on a preparative HPLC column.

WORKUP

后处理

customThe reaction solution was separated on a preparative HPLC column

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd7d7b6d9e3043f59fb9ab8dad77dbe8
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08541462B2
来源说明: uspto-grants-2013_09

反应 SMILES

[CH2:1]([O:8][C:9](=[O:44])[NH:10][C@H:11]([C:16](=[O:43])[NH:17][C@@:18]1([C:33](=[O:42])[NH:34][C@H:35]([C:40]#[N:41])[CH2:36][CH:37]([CH3:39])[CH3:38])[CH2:30][C:29]2[C:28]3[C:23](=[C:24]([Cl:32])[CH:25]=[C:26]([Cl:31])[CH:27]=3)[NH:22][C:21]=2[CH2:20][CH2:19]1)[CH:12]([CH3:15])[CH2:13][CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:45]=[N+:46]=[N-:47].[Na+].[Cl-].[NH4+]>CN(C=O)C>[CH2:1]([O:8][C:9](=[O:44])[NH:10][C@H:11]([C:16](=[O:43])[NH:17][C@@:18]1([C:33](=[O:42])[NH:34][C@H:35]([C:40]2[NH:47][N:46]=[N:45][N:41]=2)[CH2:36][CH:37]([CH3:38])[CH3:39])[CH2:30][C:29]2[C:28]3[C:23](=[C:24]([Cl:32])[CH:25]=[C:26]([Cl:31])[CH:27]=3)[NH:22][C:21]=2[CH2:20][CH2:19]1)[CH:12]([CH3:15])[CH2:13][CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1