HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline → 6-Methoxy-4-(2-methylindol-6-yloxy)-7-(3-morpholinopropoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline | HCID 11823941 | — |
| Reactant | 2-Methyl-1H-indol-6-ol | HCID 14878596 | — |
| Product | 6-Methoxy-4-(2-methylindol-6-yloxy)-7-(3-morpholinopropoxy)quinazoline | HCID 22030898 | 73% |
Reaction Steps
Using an analogous procedure to that described for Example 121, 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline (160 mg, 0.47 mol), (prepared as described for the starting material in Example 1), was reacted with 6-hydroxy-2-methylindole (84 mg, 0.57 mol), (Eur. J. Med. Chem. 1975, 10, 187), to give 6-methoxy-4-(2-methylindol-6-yloxy)-7-(3-morpholinopropoxy)quinazoline (157 mg, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-f56fd016c71b459d94803ccc2862dd02 |
| Source note | uspto-grants-2013_07 |