反应详情

4-Chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline hydrochloride was suspended in methylene chloride (10 ml) and saturated aqueous sodium hydrogen carbonate solution (5 ml) then stirred vigorously for 10 minutes at ambient temperature. The layers were separated and the organic layer dried (MgSO4) then evaporated to give a white solid. This solid was triturated with methanol (2.5 ml), the resulting solid filtered off, washed with cold methanol and dried to give 4-chloro-6-methoxy-7-(2-piperidinoethoxy)quinazoline (0.36 g).

1. customThe layers were separated
2. dry with materialthe organic layer dried (MgSO4)
3. customthen evaporated
4. customto give a white solid
5. customThis solid was triturated with methanol (2.5 ml)
6. filtrationthe resulting solid filtered off
7. washwashed with cold methanol
8. customdried