Ammonia → HCID 22030791, compound

HRID 454187Notes

Reaction equation

HRID 454187 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[C:11]([O:16][CH3:17])[CH:10]=2)=O)C.[NH3:18]>CO>[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[C:11]([O:16][CH3:17])[CH:10]=2)(=[O:3])[NH2:18]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21865246Ethyl 7-methoxyquinoline-3-carboxylate

Product 1

HCID 22030791HCID 22030791, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-Ethoxycarbonyl-7-methoxyquinoline (28 g, 120 mmol) was added to a methanol solution saturated with ammonia. The suspension was stirred at ambient temperature in a glass pressure vessel for 2 weeks. The white solid was collected by filtration, washed with methanol and dried under vacuum to give 3-carbamoyl-7-methoxyquinoline (21 g, 86%).

Workup

  1. filtrationThe white solid was collected by filtration
  2. washwashed with methanol
  3. customdried under vacuum

Sources & evidence

ORD record
ord-10e318a94480418387df078044af0f0f
Source dataset
uspto-grants-2013_07
Patent number
US08492560B2

Reaction notes

Loading…