反应详情

A solution of 7-benzyloxy-6-methoxy-4-(quinolin-7-yloxy)quinazoline (1.50 g, 3.70 mmol), (prepared as described in Example 196), in trifluoroacetic acid (50 ml) was heated at reflux for 150 minutes. The reaction was concentrated in vacuo and the reaction neutralised with saturated aqueous ammonium hydroxide. The resulting precipitate was filtered, washed with acetone and dried under suction to give 7-hydroxy-6-methoxy-4-(quinolin-7-yloxy)quinazoline (0.90 g, 2.82 mmol, 76%) as a white solid.

1. temperatureat reflux for 150 minutes
2. concentrationThe reaction was concentrated in vacuo
3. customthe reaction neutralised with saturated aqueous ammonium hydroxide
4. filtrationThe resulting precipitate was filtered
5. washwashed with acetone
6. customdried under suction