Ammonium formate → HCID 135763120, compound

HRID 454202Notes

Reaction equation

Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([NH:20][C:21]3[CH:22]=[C:23]4[C:27](=[CH:28][CH:29]=3)[NH:26][C:25]([CH3:30])=[CH:24]4)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:31][CH3:32])C1C=CC=CC=1.C([O-])=O.[NH4+]>>[OH:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([NH:20][C:21]3[CH:22]=[C:23]4[C:27](=[CH:28][CH:29]=3)[NH:26][C:25]([CH3:30])=[CH:24]4)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:31][CH3:32]

Participants

Reactant 2

HCID 2723923Ammonium formate

HCID 22030757HCID 22030757, compound

Product 1

HCID 135763120HCID 135763120, compoundYield 93.2%

Procedure

Using an analogous procedure to that described for the synthesis of the starting material in Example 201, 7-benzyloxy-6-methoxy-4-(2-methylindol-5-ylamino)quinazoline hydrochloride (2.87 g, 6.4 mmol) was reacted with ammonium formate (6 g, 9.6 mmol) to give 7-hydroxy-6-methoxy-4-(2-methylindol-5-ylamino)quinazoline (1.91 g, 93%).

Sources & evidence

ORD record: ord-b7b58ded297248f496a65d53f94d37ac
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492560B2

Reaction notes

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