Dichloromethane → HCID 22030751, compound

HRID 454217Notes

Reaction equation

HRID 454217 reaction equation
[C:1]([CH2:4][C:5]1[C:6]([F:15])=[C:7]([F:14])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])(=[O:3])[CH3:2].O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[CH:34](OC)(OC)[O:35]C.[CH2:41](Cl)Cl>>[F:14][C:7]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:5]([CH2:4][C:1]([O:35][CH3:34])([O:3][CH3:41])[CH3:2])[C:6]=1[F:15]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 9005Trimethyl orthoformateHCID 142688761-(2,3-Difluoro-6-nitrophenyl)propan-2-oneHCID 71586775Bentonite

Product 1

HCID 22030751HCID 22030751, compoundYield 88%

Procedure

A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with methylene chloride
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-1178c177a3314f07bb24ac25871386d9
Source dataset
uspto-grants-2013_07
Patent number
US08492560B2

Reaction notes

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