HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22030751, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 1-(2,3-Difluoro-6-nitrophenyl)propan-2-one | HCID 14268876 | — |
| Reactant | Bentonite | HCID 71586775 | — |
| Product | HCID 22030751 | HCID 22030751 | 88% |
Reaction Steps
A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1178c177a3314f07bb24ac25871386d9 |
| Source note | uspto-grants-2013_07 |