反应详情

To a suspension of 0.34 g (8.0 mmol) of LiAlH4 in 25 mL of THF, 1.04 g (2.50 mmol) of 31 was added. The obtained mixture was stirred for 4 hr, and then saturated aqueous solution of Na2SO4 was added. The organic layer was separated, and the aqueous layer was washed with 2×50 mL of diethyl ether. The combined organic extract was evaporated to dryness. The product was isolated by flash-chromatography on silica gel 60 (40-63 um, eluent: from hexanes to hexanes-ether, 20:1, vol.) to give 0.86 g (82%) of F1.

1. additionwas added
2. customThe organic layer was separated
3. washthe aqueous layer was washed with 2×50 mL of diethyl ether
4. extractionThe combined organic extract
5. customwas evaporated to dryness
6. customThe product was isolated by flash-chromatography on silica gel 60 (40-63 um, eluent: from hexanes to hexanes-ether, 20:1, vol.)