4-Methyl-5-(2-hydroxyethyl)thiazole → HCID 22030860, compound

HRID 454324Notes

Reaction equation

HRID 454324 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:21]=[C:20]4[C:16]([CH:17]=[CH:18][NH:19]4)=[CH:15][CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[O:22][CH3:23].O[CH2:25][CH2:26][C:27]1[S:31][CH:30]=[N:29][C:28]=1[CH3:32]>>[CH3:23][O:22][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[O:1][CH2:25][CH2:26][C:27]1[S:31][CH:30]=[N:29][C:28]=1[CH3:32])[N:9]=[CH:8][N:7]=[C:6]2[NH:12][C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 135763107HCID 135763107, compound

Product 1

HCID 22030860HCID 22030860, compoundYield 34%

Procedure

Using an analogous procedure to that described in Example 201, 7-hydroxy-4-(indol-6-ylamino)-6-methoxyquinazoline (98 mg, 0.32 mmol), (prepared as described for the starting material in Example 217), was reacted with 5-(2-hydroxyethyl)-4-methylthiazole (69 mg, 0.48 mmol) to give 6-methoxy-4-(indol-6-ylamino)-7-(2-(4-methylthiazol-5-yl)ethoxy)quinazoline (47 mg, 34%).

Workup

  1. custom(prepared

Sources & evidence

ORD record
ord-00977c2fbf9449289e9538071acff4a1
Source dataset
uspto-grants-2013_07
Patent number
US08492560B2

Reaction notes

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