Trifluoroacetic acid → HCID 46316976, compound

HRID 454499Notes

Reaction equation

HRID 454499 reaction equation
FC(F)(F)C(O)=O.C([O:15][C:16]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[CH:21][C:17]=1[C:18]([OH:20])=[O:19])C1C=CC=CC=1>>[OH:15][C:16]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[CH:21][C:17]=1[C:18]([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66990191HCID 66990191, compound

Product 1

HCID 46316976HCID 46316976, compound

Procedure

Trifluoroacetic acid (6.0 mL) was added to 2-(benzyloxy)-5-(pyridin-3-yl)benzoic acid (0.31 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the obtained residue. The solid substance was collected by filtration to obtain 2-hydroxy-5-(pyridin-3-yl)benzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and ethyl acetate
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-4e782af12637481496db959bb91265f3
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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