HCID 58508626, compound → HCID 46853577, compound

HRID 454532Notes

Reaction equation

HRID 454532 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:19]=[CH:18][C:10]=2[C:11]([O:13]C(C)(C)C)=[O:12])=[O:7])=[C:4]([OH:30])[CH:3]=1>FC(F)(F)C(O)=O.C(Cl)Cl>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:19]=[CH:18][C:10]=2[C:11]([OH:13])=[O:12])=[O:7])=[C:4]([OH:30])[CH:3]=1

Participants

4

Reactant 1

HCID 58508626HCID 58508626, compound

Product 1

HCID 46853577HCID 46853577, compoundYield 80.7%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution mixture of the obtained tert-butyl 2-(4-chloro-2-hydroxybenzamido)-4-phenylbenzoate (0.11 g) in trifluoroacetic acid (5 mL) and methylene chloride (2.5 mL) was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the residue. The solid substance was collected by filtration to obtain 0.077 g of 2-(4-chloro-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  2. additionwas added to the residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-ac5aa06acc6346a6af8b625106484b45
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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