1,4-Dioxane hydrochloride → HCID 66990698, compound

HRID 454534Notes

Reaction equation

HRID 454534 reaction equation
[ClH:1].O1CCOCC1.[OH:8][C:9]1[CH:38]=[CH:37][C:36]([N:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[CH:35][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][CH3:34])[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[ClH:1].[OH:8][C:9]1[CH:38]=[CH:37][C:36]([N:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[CH:35][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][CH3:34])[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58508681HCID 58508681, compound

Product 1

HCID 66990698HCID 66990698, compound

Procedure

A 4 mol/L hydrogen chloride-dioxane solution (3.0 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate (0.025 g), followed by stirring at room temperature for 3 hours and then at 50 to 55° C. for 1 hour. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.020 g of 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoic acid hydrochloride as a white solid.

Workup

  1. waitat 50 to 55° C. for 1 hour
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customthe solvent was evaporated under reduced pressure
  4. additionDiisopropyl ether was added to the obtained residue
  5. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-665433e844064887aef537a87a3934e9
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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