1,4-Dioxane hydrochloride → HCID 66990698, compound

Participants

Reaction Steps

A 4 mol/L hydrogen chloride-dioxane solution (3.0 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoate (0.025 g), followed by stirring at room temperature for 3 hours and then at 50 to 55° C. for 1 hour. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.020 g of 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-(2-methoxyphenyl)benzoic acid hydrochloride as a white solid.

Provenance & Evidence