Trifluoroacetic acid → HCID 46853617, compound

HRID 454539Notes

Reaction equation

HRID 454539 reaction equation
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:36]=[C:35]([N:37]2[CH:41]=[CH:40][CH:39]=[N:38]2)[CH:34]=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[OH:8][C:9]1[CH:36]=[C:35]([N:37]2[CH:41]=[CH:40][CH:39]=[N:38]2)[CH:34]=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58508881HCID 58508881, compound

Product 1

HCID 46853617HCID 46853617, compound

Procedure

A trifluoroacetic acid (5 mL) solution of the obtained tert-butyl 2-(2-hydroxy-4-(1H-pyrazol-1-yl)benzamido)-4-phenylbenzoate was stirred at room temperature for 3 hours and 30 minutes. The solvent was evaporated under reduced pressure, and methanol was added to the obtained residue. The solid substance was collected by filtration to obtain 0.056 g of 2-(2-hydroxy-4-(1H-pyrazol-1-yl)benzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and methanol
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-86023b6f30ac47bb96d4b8aed4e99126
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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