HCID 58508932, compound → HCID 58508529, compound

HRID 454544Notes

Reaction equation

HRID 454544 reaction equation
[OH:1][C:2]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>C(Cl)Cl.FC(F)(F)C(O)=O>[OH:1][C:2]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

Participants

4

Reactant 1

HCID 58508932HCID 58508932, compound

Product 1

HCID 58508529HCID 58508529, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent2×

Procedure

A solution mixture of the obtained tert-butyl 2-(2-hydroxy-4-phenylbenzamido)-4-phenylbenzoate in methylene chloride (6 mL) and trifluoroacetic acid (1 mL) was stirred at room temperature for 3 hours and 10 minutes. Trifluoroacetic acid (2 mL) was added to the reaction mixture, followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 0.076 g of 2-(2-hydroxy-4-phenylbenzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. stirringby stirring at room temperature for 1 hour
  2. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  3. additionwas added to the obtained residue
  4. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-053a6474fe4849619cf7a20f4c9e3d1b
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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